Deep brain stimulation (DBS) is a targeted circuit-based treatment that has been used to treat severe cases of OCD.11 DBS involves electrical stimulation delivered through electrodes implanted in deep structures in the brain to modulate neural circuits. DBS is targeted to the anterior limb of the internal capsule (ALIC), which receives connections from the OFC and ACC.11,12 Advances in DBS technology now allow for MR imaging to be performed while DBS is On/Off. With these advances in technology, we can now comprehensively anatomically map the impact of DBS across the brain using fMRI. These objective biomarkers of OCD, therapeutic response, and related psychiatric symptoms can in turn be used to develop more efficient, data-driven approaches to identifying optimal DBS settings that improve outcomes and minimize adverse side effects.
For our stimulation-based functional MRI (sb-fMRI) study, we plan to enroll patients who have previously or will be implanted with the FDA HDE-approved Medtronic Percept DBS system for treatment refractory OCD.
***We are currently not recruiting for this study***
